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You can't remove these fields from the page layout. But you can ovrride the whole page layout.
Please refer the below link
http://rjpalombo.com/2012/04/override-a-standard-salesforce-page-with-visualforce/
Thanks
Please check the link given below:
https://www.greytrix.com/blogs/salesforce/2015/02/02/hiding-non-removable-fields-from-a-page-layout/
Thanks.