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Set/Update Dependent Picklist Dependencies via External Program and SFDC API's

I have a client that uses four dependent picklist fields on the Product record to filter the desired products for selection (Product, Category, Sub-Category and Brand).  Each of the picklist have approximately 20 fields.  The picklist dependencies (include) need to be changed occasionally.  The details on the new dependency requirements are available in an external application and can be provided to an external interface program for update to SFDC.  I found this link suggesting that it is possible.  However, my developer indicates that it is no longer available in the SFDC API.  https://developer.salesforce.com/docs/atlas.en-us.api_meta.meta/api_meta/meta_picklist.htm
Has anyone found a way to periodcially update the picklist values and dependencies (includes) via an internal or external program.  If so, could you please share the details.

Thanks very much for your response.