Hi VKR,

Try this, worked for me.

Create a home page component of type HTML, with following code

(don't forget to check 'show HTML' checkbox, and make sure component position is 'Narrow (Left) Column')

<script type="text/javascript" src="https://ajax.googleapis.com/ajax/libs/jquery/1.7.1/jquery.min.js"></script>
<script type="text/javascript" src="https://ap1.salesforce.com/soap/ajax/25.0/connection.js"></script>
<script type="text/javascript" src="https://ap1.salesforce.com/soap/ajax/25.0/apex.js"></script>
<script>
$j = jQuery.noConflict();
$j(document).ready(function() {
var objectPefix = window.location.href.substring( window.location.href.indexOf('.com/') + 5, window.location.href.indexOf('.com/') + 8 );
var changeOwnerPrefix = window.location.href.substring( window.location.href.indexOf('.com/') + 20, window.location.href.indexOf('.com/') + 22 );
if(objectPefix=='001' && changeOwnerPrefix=='/a'){
var sid = getCookie('sid');
var server = "https://" + window.location.host + "/services/Soap/u/27.0";
sforce.connection.init(sid, server);
var currentUser = sforce.connection.getUserInfo();
var profileId = currentUser.profileId;
if(profileId.substring(0,15)=='YOURPROFILEID'){
document.getElementById("transClosedOpps").disabled=true;
var labels = document.getElementsByTagName('label');
for (var i = 0; i < labels.length; i++) {
if(labels[i].htmlFor=='transClosedOpps'){
labels[i].innerHTML='Transfer closed opportunities (has been disabled, please contact your system admin for assistance)';
}
}
}
}
});
</script>

Just replace 'YOURPROFILEID' with the id of the profile (15 digits) for which you need to disable the checkbox.

Then add the home page component to the home page layout associated with above profile.

Regards,

Vijay_Naik