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Non-Native App Architectures



Can someone explain to me what architectures non-native apps like BigMachines or Veeva operate on (their own? a third parties'?)? How they work? And how they integrate with Salesforce.com (how is the data shared between both infrastructures)?


I'm trying to understand why those non-native apps do not use the Salesforce.com infrastructure, and choose to use their own. Wouldn't this cause additional concern over performance and security as data is now located on two separate servers?