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Nitin tronixdevNitin tronixdev 

How To Change Complete Salesforce's Look and Feel

I want to change salesforce's complete look and feel inlcuding its header part too ....

Is it possible to do it ?

It is, but you'd have to replicate every page (or all the functionality) you needed in Visualforce. Its a very bad idea, as there's a huge upfront development cost and all ongoing maintenance requires an expensive developer skillset.  I have done this once in the past, although I fought hard against it, and it probably took 15-18 man months.